I used to really like FogBugz but the latest version got all glitzy and went AJAX on me and now while it does some cool stuff it's gotten a lot slower. My only other complaint is that it's built to be cross-platform (PHP or ASP), which is admirable
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Read the complete post at http://weblogs.asp.net/rhoward/archive/2007/04/17/fogbugz-and-i-are-having-a-falling-out.aspx